Université Laval
Faculté des sciences
et de génie

Patrick Lagüe

Professeur agrégé

Patrick Lagüe se spécialise dans la modélisation moléculaire de molécules biologiques, et plus particulièrement dans les interactions entre les protéines et les membranes biologiques. Il est aussi directeur du programme de baccalauréat en bio-informatique.

Champs d'intérêts

  • Modélisation moléculaire de molécules d'intérêt biologique
  • Structure et dynamique des protéines et des lipides
  • Interactions entre les protéines et les membranes cellulaires
Patrick Lagüe, professeur au Département de biochimie, de microbiologie et de bio-informatique

La liste complète se trouve sur le site de l'Institut de biologie intégrative et des systèmes.

  • Cardinal, S., Bouchard, C., Barbeau, X ., Lagüe, P. , Voyer, N. (2016) Interfacial supramolecular biomimetic epoxidation catalyzed by cyclic dipeptides. Supramolecular chemistry . Accepted for publication.
  • Ouellet, C., Maltais, R., Ouellet, É., Barbeau, X ., Lagüe, P. , Poirier, D. (2016) Discovery of a sulfamatebased steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties. Eur. J. Med. Chem. 119 :169182.
  • Paz Ramos, A., Lagüe, P ., Lamoureux, G., Lafleur, M. (2016) Effect of Saturated Very LongChain Fatty Acids on the Organization of Lipid Membranes: A Study Combining 2H NMR Spectroscopy and Molecular Dynamics Simulations. J. Phys. Chem. B 120 :69516960.
  • IyombeEngembe, J.P.? Ouellet, D. L.? Barbeau, X .? Rousseau, J.? Chapdelaine, P.? Lagüe , P.? Tremblay, J. P. (2016). Efficient Restoration of the Dystrophin Gene Reading Frame and Protein Structure in DMD Myoblasts Using the CinDel Method. Molecular Therapy Nucleic Acids 5 (1) e283.
  • Vincent, A. T., EmondRheault, J.G., Barbeau, X ., Attéré, S. A., Frenette, M., Lagüe, P. , Charette, S. J. (2016) Antibiotic resistance due to an unusual ColE1type replicon plasmid in Aeromonas salmonicida. Microbiology 162 :942953.
  • Maltais, R.? Trottier, A.? Barbeau, X.? Lagüe, P.? Perreault, M.? Thériault, J.F. ? Lin, S.X.? Poirier, D. (2015) Impact of structural modifications at positions 13, 16 and 17 of 16?(mcarbamoylbenzyl) estradiol on 17?hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity. J. Ster. Bioch. Mol. Biol. 161:2435.
  • Shayhidin, E.? Forcellini, E. ? Boulanger, M.C. ? Mahmut, A.? Dautrey, S.? Barbeau, X.? Lague, P .? Sévigny, J.? Paquin, J.F.? Mathieu, P. (2015). Quinazolin4piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathologic mineralization of valve interstitial cells. British J. of Pharm. 172 (16) 41894199. (FRQNT Team Grant)
  • Blais, S. P.? Kornblatt, J. A.? Barbeau, X. ? Bonnaure, G.? Lagüe, P. ? Chênevert, R.? Lapointe, J. (2015). tRNAGlu increases the affinity of GlutamyltRNA synthetase for its inhibitor GlutamylSulfamoylAdenosine, an analogue of the aminoacylation reaction intermediate GlutamylAMP: mechanistic and evolutionary implications. PLoS One . 10 (4): e0121043. (FRQNT Team Grant)
  • Maltais, R.? Trottier, A.? Delhomme, A.? Barbeau, X. ? Lagüe, P .? Bouchard, J.E.? Poirier, D. (2015). Identification of fused 16?,17?oxazinoneestradiol derivatives as a new family of nonestrogenic 17?hydroxysteroid dehydrogenase type 1 inhibitor. Eur. J. Med. Chem . 93 : 47080.
  • Rheault, J.F.? Gagné, E.? Guertin, M.? Lamoureux, G.? Auger, M.? Lagüe, P. (2015). Molecular model of hemoglobin N from Mycobacterium tuberculosis bound to lipid bilayers: a combined spectroscopic and computational study. Biochemistry. 54 (11): 207384. (FRQNT Team Grant)
  • Wang, Y., X. Barbeau , Y. Yanga, A. Bilimoria, P. Lagüe , M. Couture and J. K.H. Tanga. (2015). Peroxidase Activity and Involvement in the Oxidative Stress Response of Roseobacter denitrificans Truncated Hemoglobin. PLoS One. 10 (2): e0117768.
  • Légaré, S.; Lagüe, P., (2014) "The influenza fusion peptide promotes lipid polar head intrusion through hydrogen bonding with phosphates and N-terminal membrane insertion depth", Proteins: Structure, Function, and Bioinformatics (sous presse) doi:10.1002/prot.24568
  • Maltais, R.; Ayan, D.; Trottier, A.; Barbeau, X.; Lagüe, P.; Bouchard, J.-E.; Poirier, D., (2014) "Discovery of a non-estrogenic irreversible inhibitor of 17?-hydroxysteroid dehydrogenase type 1 from 3-substituted-16?-(m-carbamoylbenzyl)-estradiol derivatives.", J. Med. Chem., 57(1), 204-22, doi: 10.1021/jm401639v
  • Dallaire-Dufresne, S.; Barbeau, X.; Sarty, D.; Tanaka, K.H.; Denoncourt, A.M.; Lagüe, P.; Reith, M.E.; Charette, S.J., (2013) "Aeromonas salmonicida Ati2 is an effector protein of the type three secretion system.", Microbiology, 159(Pt 9), 1937-45, doi: 10.1099/mic.0.067959-0
  • Lorin, A.; Noël, M.; Provencher, M.-È.; Turcotte, V.; Cardinal, S.; Lagüe, P.; Voyer, N.; Auger, M., (2012) "Determining the mode of action involved in the antimicrobial activity of synthetic peptides: a solid-state NMR and FTIR study.", Biophys. J., 103(7), 1470-9, doi: 10.1016/j.bpj.2012.08.055
  • Légaré, S.; Lagüe, P., (2012) "The influenza fusion peptide adopts a flexible flat V conformation in membranes.", Biophys. J., 102(10), 2270-8, doi: 10.1016/j.bpj.2012.04.003

  • Ph. D. en chimie physique, Université de Montréal, 2001
  • M. Sc. en biophysique, Université du Québec à Trois-Rivières (UQTR), 1995
  • B. Sc. en biophysique, Université du Québec à Trois-Rivières (UQTR), 1993